GHK-Cu is a synthetic coordination complex combining the tripeptide glycyl-L-histidyl-L-lysine (GHK) with a copper(II) ion. At the biochemical level, research indicates that the GHK peptide possesses a high binding affinity for copper, facilitating its structural coordination and subsequent interaction with cellular membranes. In experimental laboratory models, this complex is primarily utilized to investigate the modulation of gene expression, particularly the biochemical pathways associated with extracellular matrix protein synthesis and degradation. Research frequently employs GHK-Cu compounds to explore metallopeptide interactions, intracellular signaling cascades, and fundamental cellular responses to copper-peptide complexes in isolated environments.